Vinod K Tiwari, Glycoscience, Dendrimer, Click Chemistry, Catalysis, BtRC,

Our current research is mainly focused on different aspects of carbohydrate chemistry, such as their modifications, application in synthesis, and development of carbohydrate-based molecules of great chemotherapeutic value. The special interest is devoted to Click Chemistry in Glycoscience particularly for the development of glycohybrids and glycodendrimers of diverse application in chemistry, biology, and medicine. The research group has gained high credit, particularly for the development of novel synthetic methodologies using benzotriazole ring cleavage (BtRC) methodology. Recently, the total synthesis of naturally occurring molecules such as imino sugars, Sialic acids, etc has also been in focus in our lab.

Ongoing Research @ VKT Lab at BHU:

Representative Selected Publications:

M S Yadav, V K Pandey, M K Jaiswal, S K Singh, A Sharma, M Singh, V K Tiwari*, Late-Stage Functionalization Strategies of 1,2,3-Triazoles: A Post-Click Approach in Organic Synthesis. J. Org. Chem., 2025, 90, 5731-5762 (Invited Perspective).
G. Negi, V.K. Pandey, P. S. Potharaju, M. K. Jaiswal, K. H. Harshan, V. K. Tiwari*, N. Parveen,* SARS-CoV-2 Evolved Variants Bind to Sialylated Gangliosides and Inhibited by Tetravalent Sialo-Glycocluster, ACS Infectious Disease, 2025, 11, 3036–3049 (Cover Page Article).
V. K. Pandey, M K Jaiswal, M S Yadav, D Ansari, S Maurya, and V. K. Tiwari*, Copper(I)-Catalyzed Tandem One-Pot Synthesis of Bis(1,2,3-triazoles) and Tetrakis (1,2,3-triazole) Glycoconjugates, Eur. J. Org. Chem., 2025, e202500491 (Highlighted Paper, hot topic: Click Chemistry).
D. Ansari, M. K. Jaiswal, M. S. Yadav, V. K. Pandey, M. Singh, V. K. Tiwari*, Biocompatible Silicomolybdic Acid Promoted One-Pot Expeditious Synthesis of 1,2,3-NH-Triazoles. Org. Biomol. Chem., 2025, 4045-4057.
M S Yadav, M K Jaiswal, S Kumar, S K Singh, S Garai, and V K Tiwari,* Substrate-Dependent Stereoselective Synthesis of Pyrrolo[3,4-b]pyridin-5-ones and Pyridyl-isoindoline-1-ones using bis(benzo triazol-1-yl) Ligand, Chem. Asian J., 2025, e202401301 (Invited paper as part of the celebration of 25 Years of CRSI).
M K Jaiswal, M K Yadav, M Singh, S Garai, V K Tiwari*, Silicomolybdic acid cluster as biocompatible catalyst for one-pot tandem synthesis of orthogonally protected glycosides, J. Org. Chem. 2024, 89, 10698–708 (Invited article).
M K Jaiswal, MS Yadav, S Maurya, D Ansari, and V. K. Tiwari,* HFIP-Mediated Synthesis of 4-Aryl-NH-1,2,3-Triazoles and 1,5-Disubstituted 1,2,3-Triazolyl Glycoconjugates J. Org. Chem., 2024, 89, 17213–17227.
M. K. Jaiswal, A. Gupta, M. S. Yadav, V. K. Pandey, and V. K. Tiwari,* Organocatalyzed Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazolyl Glycoconjugates, Chem. Eur. J., 2023, 29, e202301749.
S. K. Singh, S. Kumar, M. S. Yadav, A. Gupta, and V. K. Tiwari,* Triazole-appended Glycohybrid/ CuI Catalyzed C-C Cross-Coupling of Aryl/ Hetero Aryl Halides with Alkynyl Sugars, J. Org. Chem., 2023, 89, 13440–13453.
S K Singh, S Kumar, M S Yadav, and V. K. Tiwari,* Pyridyl Glycosyl Triazole/CuI-Mediated Domino/Tandem Synthesis of Quinazolinones, J. Org. Chem., 2022, 87, 15389-15402 (Highlighted, Organic Chemistry Portal).
N. Mishra, S. K. Singh, A. K. Agrahari, A. S. Singh, and V. K. Tiwari*, Glycosyl Triazole ligand for Temperature-Dependent Competitive Reactions of Cu-catalyzed Sonogashira coupling and Glaser Coupling, J. Org. Chem., 2021, 87, 17884-17895 (Highlighted in Organic Chemistry Portal).
V. K. Tiwari*, Development of Biologically Relevant Glycohybrid Molecules: Twenty Years of Our Journey, Chem. Rec., 2021, 21, 3029-3048 (Invited article, Recent Advances in Carbohydrate Chemistry).
Tiwari, V. K. et al., Cu(I)-catalyzed Click Chemistry in Glycoscience and their Applications. Chem. Rev., 2021, 121, 7638-7956 (Invited article for thematic issue on Click Chemistry).
Synthesis of Benz-Fused Azoles viaC-Heteroatom Coupling Reactions Catalyzed by Cu(I) in the presence of Glycosyltriazole Ligands, N. Mishra, A. S. Singh; A. K. Agrahari; S. Singh; M. Singh; V K Tiwari,* ACS Combinatorial Science, 2019, 21(5), 389–399
V. K. Tiwari,* B. B. Mishra, K. B. Mishra, N. Mishra, A. S. Singh, X. Chen, Cu(I)-Catalyzed Click Reaction in Carbohydrate Chemistry, Chem. Rev., 2016, 116, 3086-3240 (Most read article).
A Mishra and V K Tiwari*, One-pot Synthesis of Glycosyl-β-Azidoester via Diazotransfer reaction towards an easy access of Glycosyl-β-Triazolyl Ester, J. Org. Chem., 2015, 80, 4869 - 4881.
K B Mishra and V K Tiwari*, Click Chemistry Inspired Synthesis of Diverse Morpholine-fused Triazoles, J. Org. Chem., 2014, 79, 5752-5762.
D Kumar, B B Mishra and V K Tiwari*, Synthesis of 2-N/S/C-substituted Benzothiazoles via Intramolecular Cyclative Cleavage of Benzotriazole Ring, J. Org. Chem., 2014, 79, 251-265.
D Kumar, A Mishra, BB Mishra, S Bhattacharya, and V K Tiwari*, Synthesis of Glycoconjugate Benzothiazoles via Cleavage of Benzotriazole Ring, J. Org. Chem., 2013, 78, 899-909.
D. Kushwaha and V. K. Tiwari*, Click Chemistry Inspired Synthesis of Porphyrin Glycodendrimers, J. Org. Chem., 2013, 78, 8184−8190.
V Prasad, R R Kale, B B Mishra, D Kumar, and V K Tiwari*, Diacetoxyiodobenzene Mediated One-Pot Synthesis of Diverse Carboxamides from Aldehydes, Org. Lett., 2012, 14, 2936-2939.
H Yu, J Cheng, L Ding, Z Khedri, Y Chen, K Lau, V K Tiwari, X Chen, Chemoenzymatic Synthesis of GD3 Oligosaccharides and other Disialyl Glycans containing Natural and non-natural Sialic Acids. J. Am. Chem. Soc., 2009, 131, 18467-18477.
B B Mishra and V K Tiwari*, Natural Products: An evolving role in future drug discovery, Eur. J. Med. Chem., 2011, 46, 4769-4807 (Most Read Article, Citation: 1285)